| League | : | Major League Soccer | |
| Season | : | 2025 | |
| Association | : |  United States Soccer Federation | |
| Edition | : | 30th | |
| Teams | : | 30 | |
| Current champions | : | Columbus Crew SC (2024) | |
| Promoted teams | : | - | |
| Total matches | : | 493 | |
| Dates | : | 22 February – 18 December 2025 | |
Venues
| Team | Location | Stadium | Capacity |
|---|---|---|---|
 Atlanta United FC | Atlanta, Georgia | Mercedes-Benz Stadium | 42,500 |
 Austin FC | Austin, Texas | Q2 Stadium | 20,738 |
 CF Montréal | Montreal, Quebec | Saputo Stadium | 19,619 |
 Charlotte FC | Charlotte, North Carolina | Bank of America Stadium | 38,000 |
 Chicago Fire FC | Chicago suburb of Bridgeview, Illinois | Soldier Field | 24,955 |
 Colorado Rapids | Denver suburb of Commerce City, Colorado | Dick's Sporting Goods Park | 18,061 |
 Columbus Crew SC | Columbus, Ohio | Lower.com Field | 20,011 |
 D.C. United | Washington, D.C. | Audi Field | 20,000 |
 FC Cincinnati | Cincinnati, Ohio | TQL Stadium | 26,000 |
 FC Dallas | Dallas suburb of Frisco, Texas | Toyota Stadium | 20,500 |
 Houston Dynamo FC | Houston, Texas | Shell Energy Stadium | 22,039 |
 Inter Miami CF | Fort Lauderdale, Florida | Chase Stadium | 21,550 |
 LA Galaxy | Los Angeles suburb of Carson, California | Dignity Health Sports Park | 27,000 |
 Los Angeles FC | Los Angeles, California | BMO Stadium | 22,000 |
 Minnesota United FC | Minneapolis–Saint Paul | Allianz Field | 19,400 |
 Nashville SC | Nashville, Tennessee | Geodis Park | 30,000 |
 New England Revolution | Greater Boston | Gillette Stadium | 20,000 |
 New York City FC | New York City | Yankee Stadium | 28,743 |
 New York Red Bulls | Harrison, New Jersey | Sports Illustrated Stadium | 25,000 |
 Orlando City SC | Orlando, Florida | Inter&Co Stadium | 25,500 |
 Philadelphia Union | Chester, Pennsylvania | Subaru Park | 18,500 |
 Portland Timbers | Portland, Oregon | Providence Park | 25,218 |
 Real Salt Lake | Sandy, Utah | America First Field | 20,213 |
 San Diego FC | San Diego | Snapdragon Stadium | 35,000 |
 San Jose Earthquakes | San Jose, California | PayPal Park | 18,000 |
 Seattle Sounders FC | Seattle, Washington | Lumen Field | 37,722 |
 Sporting Kansas City | Kansas City, Kansas | Children's Mercy Park | 18,467 |
 St. Louis City SC | St. Louis, Missouri | Energizer Park | 22,423 |
 Toronto FC | Toronto, Ontario | BMO Field | 28,351 |
 Vancouver Whitecaps FC | Vancouver, British Columbia | BC Place | 22,120 |
Managers
| Team | Manager | Nationality | |
|---|---|---|---|
| Atlanta United FC | Ronny Deila |  Norway | |
| Austin FC | Nico Estévez |  Spain | |
| CF Montréal | Marco Donadel (interim) |  Italy | |
| Charlotte FC | Dean Smith |  England | |
| Chicago Fire FC | Gregg Berhalter | United States | |
| Colorado Rapids | Chris Armas | United States | |
| Columbus Crew SC | Wilfried Nancy |  France | |
| D.C. United | Troy Lesesne | United States | |
| FC Cincinnati | Pat Noonan | United States | |
| FC Dallas | Eric Quill | United States | |
| Houston Dynamo FC | Ben Olsen | United States | |
| Inter Miami CF | Javier Mascherano |  Argentina | |
| LA Galaxy | Greg Vanney | United States | |
| Los Angeles FC | Steve Cherundolo | United States | |
| Minnesota United FC | Eric Ramsay |  Wales | |
| Nashville SC | B.J. Callaghan | United States | |
| New England Revolution | Caleb Porter | United States | |
| New York City FC | Pascal Jansen |  Netherlands | |
| New York Red Bulls | Sandro Schwarz |  Germany | |
| Orlando City SC | Óscar Pareja |  Colombia | |
| Philadelphia Union | Bradley Carnell |  South Africa | |
| Portland Timbers | Phil Neville | England | |
| Real Salt Lake | Pablo Mastroeni | United States | |
| San Diego FC | Mikey Varas | United States | |
| San Jose Earthquakes | Bruce Arena | United States | |
| Seattle Sounders FC | Brian Schmetzer | United States | |
| Sporting Kansas City | Kerry Zavagnin (interim) | United States | |
| St. Louis City SC | David Critchley (interim) | United States | |
| Toronto FC | Robin Fraser | United States | |
| Vancouver Whitecaps FC | Jesper Sørensen |  Denmark | |
Captains
| Team | Captain | Nationality |
|---|---|---|
| Atlanta United FC | Brad Guzan | United States |
| Austin FC | Sebastián Driussi | Argentina |
| CF Montréal | Samuel Piette |  Canada |
| Charlotte FC | Ashley Westwood | England |
| Chicago Fire FC | TBA |  TBA |
| Colorado Rapids | Keegan Rosenberry | United States |
| Columbus Crew SC | Darlington Nagbe | United States |
| D.C. United | Christian Benteke |  Belgium |
| FC Cincinnati | Luciano Acosta | Argentina |
| FC Dallas | Paul Arriola | United States |
| Houston Dynamo FC | TBA | TBA |
| Inter Miami CF | Lionel Messi | Argentina |
| LA Galaxy | TBA | TBA |
| Los Angeles FC | TBA | TBA |
| Minnesota United FC | TBA | TBA |
| Nashville SC | Walker Zimmerman | United States |
| New England Revolution | Carles Gil | Spain |
| New York City FC | Thiago Martins |  Brazil |
| New York Red Bulls | Emil Forsberg |  Sweden |
| Orlando City SC | Robin Jansson | Sweden |
| Philadelphia Union | Alejandro Bedoya | United States |
| Portland Timbers | Diego Chará | Colombia |
| Real Salt Lake | Cristian Arango | Colombia |
| San Diego FC | TBA | TBA |
| San Jose Earthquakes | TBA | TBA |
| Seattle Sounders FC | Stefan Frei |  Switzerland |
| Sporting Kansas City | Johnny Russell |  Scotland |
| St. Louis City SC | Roman Bürki | Switzerland |
| Toronto FC | Jonathan Osorio | Canada |
| Vancouver Whitecaps FC | Ryan Gauld | Scotland |