The play-off round is split into two separate sections: Champions Route (for league champions) and League Route (for league non-champions). The losing teams in both sections enter the 2016–17 UEFA Europa League group stage.
The draw for the play-off round was held on 5 August 2016. The first legs will be played on 16 and 17 August, and the second legs will be played on 23 and 24 August 2016.
The draw for the play-off round was held on 5 August 2016. The first legs will be played on 16 and 17 August, and the second legs will be played on 23 and 24 August 2016.
| Tim 1 | Agg. | Tim 2 | Leg 1 | Leg 2 |
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